The 2015-2016 regional football alignments shown below are recommendations prepared by the TSSAA staff. They will be presented to the Board of Control on Thursday, November 13, 2014. No part of these recommendations are final until approved by the Board of Control.
| School | City | ||
| Class 1A | Region 1 | Cloudland High School | Roan Mountain |
| Concord Christian | Knoxville | ||
| Greenback High School | Greenback | ||
| Hancock Co. High School | Sneedville | ||
| Unaka High School | Elizabethton | ||
| Region 2 | Coalfield High School | Coalfield | |
| Harriman High School | Harriman | ||
| Jellico High School | Jellico | ||
| Midway High School | Kingston | ||
| Oakdale High School | Oakdale | ||
| Oneida High School | Oneida | ||
| Sunbright High School | Sunbright | ||
| Region 3 | Copper Basin High School | Copperhill | |
| Grace Baptist Academy | Chattanooga | ||
| Lookout Valley High School | Chattanooga | ||
| Sale Creek School | Sale Creek | ||
| South Pittsburg High School | South Pittsburg | ||
| Whitwell High School | Whitwell | ||
| Region 4 | Columbia Academy | Columbia | |
| Cornersville High School | Cornersville | ||
| Fayetteville High School | Fayetteville | ||
| Huntland High School | Huntland | ||
| Moore Co. High School | Lynchburg | ||
| Mt. Pleasant High School | Mt. Pleasant | ||
| Richland High School | Lynnville | ||
| Summertown High School | Summertown | ||
| Region 5 | Clay Co. High School | Celina | |
| Gordonsville High School | Gordonsville | ||
| Jo Byrns High School | Cedar Hill | ||
| Middle Tennessee Christian School | Murfreesboro | ||
| Monterey High School | Monterey | ||
| Nashville Christian School | Nashville | ||
| Pickett Co. High School | Byrdstown | ||
| Red Boiling Springs High School | Red Boiling Springs | ||
| Trousdale Co. High School | Hartsville | ||
| Region 6 | Clarksville Academy | Clarksville | |
| Collinwood High School | Collinwood | ||
| Hollow Rock-Bruceton Central High School | Bruceton | ||
| Houston Co. High School | Erin | ||
| Huntingdon High School | Huntingdon | ||
| McEwen High School | Mcewen | ||
| Perry Co. High School | Linden | ||
| Wayne Co. High School | Waynesboro | ||
| Region 7 | Dresden High School | Dresden | |
| Gleason High School | Gleason | ||
| Greenfield High School | Greenfield | ||
| Humboldt High School | Humboldt | ||
| Lake Co. High School | Tiptonville | ||
| Peabody High School | Trenton | ||
| South Fulton High School | South Fulton | ||
| Union City High School | Union City | ||
| West Carroll High School | Atwood | ||
| Region 8 | B. T. Washington High School | Memphis | |
| George Washington Carver High School | Memphis | ||
| KIPP Memphis Collegiate School | Memphis | ||
| Memphis Middle College High School | Memphis | ||
| Memphis Northside High School | Memphis | ||
| Middleton High School | Middleton | ||
| W.E.B. Dubois High School | Memphis | ||
| Class 2A | Region 1 | Cosby High School | Cosby |
| Cumberland Gap High School | Cumberland Gap | ||
| Gatlinburg-Pittman High School | Gatlinburg | ||
| Hampton High School | Hampton | ||
| Happy Valley High School | Elizabethton | ||
| North Greene High School | Greeneville | ||
| South Greene High School | Greeneville | ||
| Sullivan North High School | Kingsport | ||
| Region 2 | Austin-East High School | Knoxville | |
| Grace Christian Academy | Knoxville | ||
| Oliver Springs High School | Oliver Springs | ||
| Rockwood High School | Rockwood | ||
| Sweetwater High School | Sweetwater | ||
| Tellico Plains High School | Tellico Plains | ||
| Wartburg Central High School | Wartburg | ||
| Region 3 | Bledsoe Co. High School | Pikeville | |
| Boyd Buchanan High School | Chattanooga | ||
| Brainerd High School | Chattanooga | ||
| Marion Co. High School | Jasper | ||
| Meigs Co. High School | Decatur | ||
| Polk Co. High School | Benton | ||
| Silverdale Baptist Academy | Chattanooga | ||
| Tyner Academy | Chattanooga | ||
| Region 4 | Cascade High School | Wartrace | |
| Community High School | Unionville | ||
| Eagleville High School | Eagleville | ||
| East Robertson High School | Cross Plains | ||
| Forrest High School | Chapel Hill | ||
| Jackson Co. High School | Gainesboro | ||
| Watertown High School | Watertown | ||
| Westmoreland High School | Westmoreland | ||
| Region 5 | Decatur Co. Riverside High School | Decaturville | |
| Hickman Co. High School | Centerville | ||
| Lewis Co. High School | Hohenwald | ||
| Loretto High School | Loretto | ||
| Scotts Hill High School | Reagan | ||
| Waverly Central High School | Waverly | ||
| Region 6 | Adamsville High School | Adamsville | |
| Gibson Co. High School | Dyer | ||
| Halls High School | Halls | ||
| Jackson Christian School | Jackson | ||
| McKenzie High School | Mckenzie | ||
| Trinity Christian Academy | Jackson | ||
| Region 7 | Frederick Douglass High School | Memphis | |
| Hillcrest High School | Memphis | ||
| Martin Luther King, Jr. Preparatory High School | Memphis | ||
| Memphis Academy of Health Sciences | Memphis | ||
| Trezevant High School | Memphis | ||
| Region 8 | Fairley High School | Memphis | |
| Manassas High School | Memphis | ||
| Mitchell High School | Memphis | ||
| Oakhaven High School | Memphis | ||
| Westwood High School | Memphis | ||
| Class 3A | Region 1 | Chuckey-Doak High School | Afton |
| Claiborne High School | New Tazewell | ||
| Elizabethton High School | Elizabethton | ||
| Johnson Co. High School | Mountain City | ||
| Northview Academy | Kodak | ||
| Pigeon Forge High School | Pigeon Forge | ||
| Unicoi Co. High School | Erwin | ||
| West Greene High School | Mosheim | ||
| Region 2 | Alcoa High School | Alcoa | |
| Alvin C. York Institute | Jamestown | ||
| Christian Academy of Knoxville | Knoxville | ||
| Kingston High School | Kingston | ||
| Loudon High School | Loudon | ||
| McMinn Central High School | Englewood | ||
| Scott High School | Huntsville | ||
| Region 3 | Chattanooga Christian School | Chattanooga | |
| East Ridge High School | Chattanooga | ||
| Notre Dame High School | Chattanooga | ||
| Red Bank High School | Chattanooga | ||
| Signal Mountain High School | Signal Mountain | ||
| The Howard School | Chattanooga | ||
| Region 4 | Cannon Co. High School | Woodbury | |
| DeKalb Co. High School | Smithville | ||
| Grundy Co. High School | Coalmont | ||
| Sequatchie Co. High School | Dunlap | ||
| Smith Co. High School | Carthage | ||
| Upperman High School | Baxter | ||
| Region 5 | Christ Presbyterian Academy | Nashville | |
| East Nashville Magnet School | Nashville | ||
| Goodpasture Christian School | Madison | ||
| Greenbrier High School | Greenbrier | ||
| Stratford High School | Nashville | ||
| White House Heritage High School | White House | ||
| Whites Creek High School | Whites Creek | ||
| Region 6 | Camden Central High School | Camden | |
| Cheatham Co. Central High School | Ashland City | ||
| East Hickman High School | Lyles | ||
| Fairview High School | Fairview | ||
| Harpeth High School | Kingston Springs | ||
| Stewart Co. High School | Dover | ||
| Sycamore High School | Pleasant View | ||
| Region 7 | Dyersburg High School | Dyersburg | |
| Jackson Central-Merry Academy of Medical Tech. | Jackson | ||
| Jackson South Side High School | Jackson | ||
| Liberty Technology Magnet High School | Jackson | ||
| Milan High School | Milan | ||
| South Gibson Co. High School | Medina | ||
| Westview High School | Martin | ||
| Region 8 | Bolivar Central High School | Bolivar | |
| Covington High School | Covington | ||
| Fayette-Ware Comprehensive High School | Somerville | ||
| Hamilton High School | Memphis | ||
| McNairy Central High School | Selmer | ||
| Melrose High School | Memphis | ||
| Raleigh Egypt High School | Memphis | ||
| Sheffield High School | Memphis | ||
| Class 4A | Region 1 | Cherokee High School | Rogersville |
| Grainger High School | Rutledge | ||
| Greeneville High School | Greeneville | ||
| Seymour High School | Seymour | ||
| Sullivan Central High School | Blountville | ||
| Sullivan East High School | Bluff City | ||
| Sullivan South High School | Kingsport | ||
| Volunteer High School | Church Hill | ||
| Region 2 | Anderson Co. High School | Clinton | |
| Carter High School | Strawberry Plains | ||
| Fulton High School | Knoxville | ||
| Knoxville Catholic High School | Knoxville | ||
| Knoxville Central High School | Knoxville | ||
| Union Co. High School | Maynardville | ||
| Region 3 | Chattanooga Central High School | Harrison | |
| Cumberland Co. High School | Crossville | ||
| East Hamilton High School | Ooltewah | ||
| Hixson High School | Hixson | ||
| Livingston Academy | Livingston | ||
| Sequoyah High School - Madisonville | Madisonville | ||
| Stone Memorial High School | Crossville | ||
| Region 4 | Giles Co. High School | Pulaski | |
| Lawrence Co. High School | Lawrenceburg | ||
| Marshall Co. High School | Lewisburg | ||
| Page High School | Franklin | ||
| Spring Hill High School | Columbia | ||
| Tullahoma High School | Tullahoma | ||
| Region 5 | Macon Co. High School | Lafayette | |
| Maplewood Comprehensive High School | Nashville | ||
| Pearl Cohn High School | Nashville | ||
| Portland High School | Portland | ||
| Springfield High School | Springfield | ||
| White House High School | White House | ||
| Region 6 | Creek Wood High School | Charlotte | |
| Hillwood High School | Nashville | ||
| Kenwood High School | Clarksville | ||
| Lipscomb Academy | Nashville | ||
| Montgomery Central High School | Cunningham | ||
| Northwest High School | Clarksville | ||
| Region 7 | Chester Co. High School | Henderson | |
| Crockett Co. High School | Alamo | ||
| Dyer Co. High School | Newbern | ||
| Hardin Co. High School | Savannah | ||
| Haywood High School | Brownsville | ||
| Jackson North Side High School | Jackson | ||
| Lexington High School | Lexington | ||
| Obion Co. Central High School | Troy | ||
| Ripley High School | Ripley | ||
| Region 8 | Craigmont High School | Memphis | |
| Kingsbury High School | Memphis | ||
| Memphis East High School | Memphis | ||
| Millington Central High School | Millington | ||
| Ridgeway High School | Memphis | ||
| Class 5A | Region 1 | Cocke Co. High School | Newport |
| Daniel Boone High School | Gray | ||
| David Crockett High School | Jonesborough | ||
| Morristown-Hamblen High School East | Morristown | ||
| Morristown-Hamblen High School West | Morristown | ||
| Sevier Co. High School | Sevierville | ||
| Tennessee High School | Bristol | ||
| Region 2 | Gibbs High School | Corryton | |
| Heritage High School | Maryville | ||
| Knoxville Halls High School | Knoxville | ||
| Powell High School | Powell | ||
| South Doyle High School | Knoxville | ||
| West High School | Knoxville | ||
| Region 3 | Campbell Co. High School | Jacksboro | |
| Clinton High School | Clinton | ||
| Farragut High School | Knoxville | ||
| Karns High School | Knoxville | ||
| Lenoir City High School | Lenoir City | ||
| Oak Ridge High School | Oak Ridge | ||
| Region 4 | Cleveland High School | Cleveland | |
| McMinn Co. High School | Athens | ||
| Ooltewah High School | Ooltewah | ||
| Rhea County High School | Evensville | ||
| Soddy-Daisy High School | Soddy-daisy | ||
| Walker Valley High School | Cleveland | ||
| White Co. High School | Sparta | ||
| Region 5 | Columbia Central High School | Columbia | |
| Franklin Co. High School | Winchester | ||
| Independence High School | Thompson''s Station | ||
| LaVergne High School | Lavergne | ||
| Lincoln Co. High School | Fayetteville | ||
| Shelbyville Central High School | Shelbyville | ||
| Stewarts Creek High School | Smyrna | ||
| Summit High School | Spring Hill | ||
| Region 6 | Beech Senior High School | Hendersonville | |
| Cane Ridge High School | Antioch | ||
| Gallatin High School | Gallatin | ||
| Glencliff High School | Nashville | ||
| Hendersonville High School | Hendersonville | ||
| Hillsboro High School | Nashville | ||
| Hunters Lane High School | Nashville | ||
| Station Camp High School | Gallatin | ||
| Region 7 | Brentwood High School | Brentwood | |
| Centennial High School | Franklin | ||
| Clarksville High School | Clarksville | ||
| Dickson Co. High School | Dickson | ||
| Henry Co. High School | Paris | ||
| Northeast High School | Clarksville | ||
| Rossview High School | Clarksville | ||
| West Creek High School | Clarksville | ||
| Region 8 | Bolton High School | Arlington | |
| Brighton High School | Brighton | ||
| Kirby High School | Memphis | ||
| Memphis Central High School | Memphis | ||
| Munford High School | Munford | ||
| Overton High School | Memphis | ||
| Southwind High School | Memphis | ||
| Wooddale High School | Memphis | ||
| Class 6A | Region 1 | Bearden High School | Knoxville |
| Bradley Central High School | Cleveland | ||
| Dobyns Bennett High School | Kingsport | ||
| Hardin Valley Academy | Knoxville | ||
| Jefferson Co. High School | Dandridge | ||
| Maryville High School | Maryville | ||
| Science Hill High School | Johnson City | ||
| William Blount High School | Maryville | ||
| Region 2 | Blackman High School | Murfreesboro | |
| Coffee Co. Central High School | Manchester | ||
| Cookeville High School | Cookeville | ||
| Oakland High School | Murfreesboro | ||
| Riverdale High School | Murfreesboro | ||
| Siegel High School | Murfreesboro | ||
| Smyrna High School | Smyrna | ||
| Warren Co. High School | Mcminnville | ||
| Region 3 | Antioch High School | Antioch | |
| Franklin High School | Franklin | ||
| John Overton High School | Nashville | ||
| Lebanon High School | Lebanon | ||
| McGavock High School | Nashville | ||
| Mt. Juliet High School | Mt. Juliet | ||
| Ravenwood High School | Brentwood | ||
| Wilson Central High School | Lebanon | ||
| Region 4 | Arlington High School | Arlington | |
| Bartlett High School | Bartlett | ||
| Collierville High School | Collierville | ||
| Cordova High School | Cordova | ||
| Germantown High School | Germantown | ||
| Houston High School | Germantown | ||
| White Station High School | Memphis | ||
| Whitehaven High School | Memphis |
